Harmanpreet Kaur's towering unbeaten century delivered India a resounding victory over England at Canterbury and an unassailable 2-0 ODI series lead.
India's 88-run win, built on Harmanpreet's 143 not out off 111 balls, means Saturday's finale at Lord's will be a dead rubber in the context of the series with England's best hope now claiming the two ICC Women's Championship points on offer in a consolation victory after winning the T20I leg of the tour 2-1.
Asked to achieve the first 300-plus run chase in a women's ODI after India posted 333 for 5 - their second-highest in the format, England managed 245 in reply, Danni Wyatt's half-century coming in a losing cause as Renuka Singh claimed four wickets to put the result beyond doubt, India winning with 34 balls to spare.
Having won the toss and opted to bowl first in cool and cloudy conditions, England knew the key to forcing the series to a decider at the home of cricket was to diminish the threat of India's firing top order.
Smriti Mandhana and Harmanpreet had carried their side to a commanding seven-wicket win in the opening ODI at Hove on Sunday, with 91 and 74 not out respectively, Mandhana also keeping her side in contention during the T20Is with an unbeaten 79 in the second match.
England started well enough when Kate Cross, playing her 50th ODI, bowled Shafali Verma in the second over of the match and Charlie Dean took a sharp return catch to remove Yasatika Bhatia and break a second-wicket stand of 54.
Opener Mandhana looked dangerous again though, peeling off four fours and swatting Sophie Ecclestone over the fence at wide long-on on her way to 40. But it was Ecclestone who ended Mandhana's knock with one that spun back in to beat the attempted sweep and strike the side of her back thigh for lbw. At that stage Mandhana had put on 33 runs with Kaur, who carried on in fine touch with Harleen Deol keeping pace nicely.
Deol dispatched Ecclestone down the ground for six to move to 47 and raised her fifty a short time later with a single dabbed through midwicket and then carried India past the 200-mark with another maximum, swept over deep square leg off Lauren Bell.
By the time Bell had Deol caught by Wyatt at deep midwicket, India were on track to post an imposing total and Harmanpreet was into a stunning rhythm.
Harmanpreet unleashed her signature slog-sweep to devastating effect and was also punishing to the off side, her two sixes over the covers off debutant Freya Kemp bookending a brutal slog off Ecclestone over the deep midwicket boundary.
Kemp, the 17-year-old left-arm seamer who has had an impressive maiden international summer in England's T20I team, endured a torrid introduction to the longer format. After bowling seven overs for 28 runs, she ended up conceding 82 runs off her 10-over allocation for just one wicket, that of Pooja Vastrakar, who was caught by Emma Lamb in the 46th. It was the most runs conceded by an England bowler in a women's ODI, followed by fellow seamer Bell, who took 1 for 79 from 10 overs.
Harmanpreet added the lion's share as she and Deepti Sharma piled on another 71 runs after Vastrakar's dismissal at a staggering partnership run rate of 17.75, the highest for a 50-plus stand in women's ODIs where data is available.
They took 62 runs off the last three overs, 26 of those coming off the 48th as Kemp sent down six wide deliveries and went for three fours and a six. Harmanpreet helped herself to 18 of the 19 runs Kemp conceded off the final over, including another aerial cover drive for six followed immediately by three consecutive fours to complete a stunning display.
(With inputs from agencies)